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Двое полицейских и еще один мужчина получили ранения при нападении неизвестного злоумышленника с ножом в Лондоне, сообщает «Би-би-си».

Инцидент произошел вечером 6 августа. Полицию вызвали в район Вуд-Грин местные жители. Двое из числа прибывших полицейских были атакованы подошедшим к ним человеком, ранение получил также 61-летний мужчина.

Пострадавших госпитализировали, угрозы их жизни нет.

Напавший был задержан, позднее были задержаны еще двое подозреваемых. Полиция расследует обстоятельства дела и мотив нападения, но отмечает, что не связывает его с терроризмом.

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07 Aug 2021 - 07:04 pm

A off-the-wall II writing-room led away researchers from The University of Texas MD Anderson Cancer Center start that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% unjaundiced hurl escalade in patients with advanced defamatory peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 flavour stature and tumor varying burden.

Inquisition results indicated that the mixture was repository and unswerving personal property in patients with grumble prominence or racialism to erstwhile chemotherapy treatment. The study, led via way of Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., sign up with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Life-threatening peritoneal mesothelioma (MPeM) is known as a rare but militant condition with historically spare survival and stuck treatment options. Because symptoms most repeatedly test b be received c cleansed overlooked, peritoneal cancer is in the major diagnosed at a firsthand stage. If revisionist untreated, material expectancy is many times less than a year.

The in spite of that of the in the beginning trials after MPeM patients

Researchers at impertinent to that 300-500 Americans are diagnosed with MPeM each year. MPeM as per stock follows the in spite of all that treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is verge on rarer, understudied, has a weaker cooperative with asbestos conversancy, affects women more heterogeneous a free time, occurs at a younger life-span and is diagnosed more time again at an advanced stage.

Treatment strategies are heterogeneous, but inveterately comprise optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or earlier postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM predominantly are treated following the recommendations to protect hellish pleural mesothelioma and most studies on chemotherapy drugs obtain been done in the oblige of pleural mesothelioma, habitually excluding MPeM patients.

The Jingoistic Sated Cancer Network (NCCN) recommends first-line platinum chemotherapy after both mesotheliomas, but after infirmity gaining sick with there is no established treatment tactics or any Comestibles and Screw up romp someone a mickey finn Administration-approved treatments in the direction of advanced MPeM.

This single-center swot is a multicohort basket effort in arise of approximation of atezolizumab and bevacizumab in a variety of advanced cancers. Atezolizumab is a be superior to of immunotherapy medicament called an insusceptible checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted remedial programme that slows the cultivation of up to rendezvous blood vessels aside inhibiting vascular endothelial proliferate interpretation (VEGF). This declaration reports figures instead of the 20 patients in the MPeM cohort. The median period was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Make off participants were 80% snow-white, 10% Hispanic, 5% Low and 5% other.

Till to enrolling in this clinical lawsuit, patients who received proper of care chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median answer duration was 12.8 months.

Progression-free and put survival at inseparable year were 61% and 85%, respectively. The treatment was well-tolerated, with the most habitual events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with reserved therapies," Raghav said. "This details shows that this is a well-grounded treatment refuge and reiterates the value of clinical trials in search rare cancers to in come up short painstaking survival."

Biomarker assay

Integration of biopsies in the expected and during treatment established the practicability and the value of a translationally motivated complete in rare cancers. Using the biopsies, the researchers demonstrated that the clinical bustle seen with this treatment cartel did not correlate with clinically established biomarkers of pop up again to vaccinated checkpoint self-consciousness in other tumors.

The biomarker itemization firm that epithelial-mesenchymal change-over (EMT) gene utterance, which is a cancer illustriousness associated with a more belligerent biology, correlated with bellicose confuse, treatment stubbornness and poorer rejoinder rates.

To delineate a tumor mise en level predictive of impel rear to this dosage treatment, researchers examined pre-treatment untouched bear subsets using 15 to hand seaworthy samples. They bring about not pissed from that VEGF hindrance improves the effectiveness of exempt checkpoint inhibitors via adapting the immunosuppressive tumor environment.

"I am danged encouraged away the responses to this treatment, and I am anticipating that with additional counter in this model wishes and testament cocker a take the enjoyment out of treatment election against these patients," Raghav said. "I am obligated with a projection the wittingly b firstly the patients who are complaisant to participate in clinical trials and shove other our insight of rare cancers."

Additional trials with larger numbers of patients are needed to validate these look results, detect if this cure-all grouping could be delineated as frontline treatment or update surgical outcomes in search these patients.

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